Caspase-3 mouse Monoclonal Antibody(5H10)

产品详情

产品名称

Caspase-3 mouse Monoclonal Antibody(5H10)

产品货号

YM-A03194

规格

50μL;100μL

种属反应

Human,Rat,Mouse

实验应用

WB,IHC-p,IF(paraffin section)

分子量

17、32

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB: 500-2000;IHC 1:100-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-20°C/1 year

浓度

1 mg/ml

克降性

Monoclonal

克隆号

5H10

免疫原

Synthetic Peptide of Caspase-3 at AA range of 20-100

特异性

Caspase-3 protein detects endogenous levels of CASP3

基因名称

CASP3

蛋白名称

Caspase3

别名

CASP3

基因ID-1

836

SwissProt

P42574

背景

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm.