Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody

产品详情

产品名称

Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody

产品货号

YM-A03862

规格

50μL;100μL

种属反应

Mouse,Rat

实验应用

WB,IHC,IF,ELISA

分子量

28kD,35kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:100-1:300;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from mouse Caspase 6. AA range:144-193

特异性

Cleaved-Caspase-6 p18 (D162) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-6 p18 protein resulting from cleavage adjacent to D162.

基因名称

CASP6

蛋白名称

Caspase6

别名

CASP6;MCH2;Caspase-6;CASP-6;Apoptotic protease Mch-2

基因ID-1

839

SwissProt

P55212

背景

CASP6 encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme.Caspase 6 is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of CASP6 results in multiple transcript variants that encode different isoforms.

细胞定位