Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody

产品详情

产品名称

Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody

产品货号

YM-A03876

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

22kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human Caspase 2 p18 C-ternal. AA range:276-325

特异性

Cleaved-Caspase-2 p18 (T325) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-2 p18 protein resulting from cleavage adjacent to T325.

基因名称

CASP2

蛋白名称

Caspase2

别名

CASP2;ICH1;NEDD2;Caspase-2;CASP-2;Neural precursor cell expressed developmentally down-regulated protein 2;NEDD-2;Protease ICH-1

基因ID-1

835

SwissProt

P42575

背景

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of tumorigenesis. Increased expression of this gene may play a role in neurodegenerative disorders including Alzheimer's disease, Huntington's disease and temporal lobe epilepsy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011],

细胞定位

nucleus,cytoplasm,mitochondrion,cytosol,membrane,