Cleaved-Factor B Bb (K260) Polyclonal Antibody

产品详情

产品名称

Cleaved-Factor B Bb (K260) Polyclonal Antibody

产品货号

YM-A03928

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,ELISA

分子量

57kD,85kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:20000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

The antiserum was produced against synthesized peptide derived from human CFAB Bb. AA range:241-290

特异性

Cleaved-Factor B Bb (K260) Polyclonal Antibody detects endogenous levels of fragment of activated Factor B Bb protein resulting from cleavage adjacent to K260.

基因名称

CFB

蛋白名称

Complement factor B

别名

CFB;BF;BFD;Complement factor B;C3/C5 convertase;Glycine-rich beta glycoprotein;GBG;PBF2;Properdin factor B

基因ID-1

629

SwissProt

P00751

背景

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complemen

细胞定位

Secreted.