Caspase-10 p23/17 (Cleaved-D415) rabbit pAb

产品详情

产品名称

Caspase-10 p23/17 (Cleaved-D415) rabbit pAb

产品货号

YM-A03962

规格

50μL;100μL

种属反应

Human

实验应用

WB,ELISA

分子量

23kD/17kD 55kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:1000-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human Caspase-10 p23/17 (Cleaved-D415)

特异性

This antibody detects endogenous levels of Human Caspase-10 p23/17 (Cleaved-D415, protein was cleaved amino acid sequence between 415-416)

基因名称

CASP10 MCH4

蛋白名称

Caspase10

别名

Caspase-10;CASP-10;Apoptotic protease Mch-4;FAS-associated death domain protein interleukin-1B-converting enzyme 2;FLICE2;ICE-like apoptotic protease 4;[Cleaved into: Caspase-10 subunit p23/17;Caspase-10 subunit p12]

基因ID-1

843

SwissProt

Q92851

背景

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011],

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