FA7 (light chain, Cleaved-Ala61) rabbit pAb

产品详情

产品名称

FA7 (light chain, Cleaved-Ala61) rabbit pAb

产品货号

YM-A04004

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,ELISA

分子量

17kD(light chain),51kD(full length),44kD(mature chain)

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:1000-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human FA7 (light chain, Cleaved-Ala61)

特异性

This antibody detects endogenous levels of Human FA7 (light chain, Cleaved-Ala61, protein was cleaved amino acid sequence between 60-61 )

基因名称

F7

蛋白名称

FA7 (light chain, Cleaved-Ala61)

别名

Coagulation factor VII;Proconvertin;Serum prothrombin conversion accelerator;SPCA;Eptacog alfa;[Cleaved into: Factor VII light chain;Factor VII heavy chain]

基因ID-1

2155

SwissProt

P08709

背景

catalytic activity:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.,disease:Defects in F7 are the cause of factor VII deficiency [MIM:227500]. Factor VII deficiency is a rare hereditary hemorrhagic disease. The clinical picture can be very severe, with the early occurrence of intracerebral hemorrhages or hemarthroses, or, in contrast, moderate with cutaneous-mucosal hemorrhages (epistaxis, menorrhagia) or hemorrhages provoked by a surgical intervention. Numerous subjects are completely asymptomatic despite a very low F7 level.,function:Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.,online information:Factor VII entry,online information:The Singapore human mutation and polymorphism database,pharmaceutical:Available under the names Niastase or Novoseven (Novo Nordisk). Used for the treatment of bleeding episodes in hemophilia A or B patients with antibodies to coagulation factors VIII or IX.,polymorphism:Individuals with the Q allele (Gln-413) seems to have a decreased susceptibility to myocardial infarction.,PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.,PTM:The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 Gla (gamma-carboxy-glutamate) domain.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 2 EGF-like domains.,subunit:Heterodimer of a light chain and a heavy chain linked by a disulfide bond.,tissue specificity:Plasma.,

细胞定位

Secreted.