Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

产品详情

产品名称

Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

产品货号

YM-A04051

规格

50μL;100μL

种属反应

Human,Rat,Mouse,

实验应用

WB,ELISA,IHC

分子量

28kD,70kD

宿主

Rabbit

同种型

IgG

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)

特异性

This antibody detects endogenous levels of Human Cleaved-Plasma Kallikrein LC (I391, protein was cleaved amino acid sequence between 390-391 )

基因名称

KLKB1 KLK3

蛋白名称

Plasma Kallikrein LC (Cleaved-I391)

别名

Plasma kallikrein;Fletcher factor;Kininogenin;Plasma prekallikrein;[Cleaved into: Plasma kallikrein heavy chain;Plasma kallikrein light chain]

基因ID-1

3818

SwissProt

P03952

背景

catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin.,disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect.,function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.,similarity:Belongs to the peptidase S1 family.,similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily.,similarity:Contains 1 peptidase S1 domain.,similarity:Contains 4 apple domains.,subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.,

细胞定位

Secreted.