PCAF (Acetyl Lys428) Polyclonal Antibody

产品详情

产品名称

PCAF (Acetyl Lys428) Polyclonal Antibody

产品货号

YM-A04155

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC

分子量

93kD

宿主

Rabbit

同种型

IgG

修饰

Acetyl

推荐稀释比

WB 1:500-2000;IHC 1:50-300

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized acetyl-peptide derived from the human PCAF around the acetylation site of K428.

特异性

Acetyl-PCAF (K428) Polyclonal AntibodySynthesized peptide derived from the human PCAF around the acetylation site of K428.

基因名称

KAT2B

蛋白名称

Histone acetyltransferase KAT2B

别名

KAT2B;PCAF;Histone acetyltransferase KAT2B;Histone acetyltransferase PCAF;Histone acetylase PCAF;Lysine acetyltransferase 2B;P300/CBP-associated factor;P/CAF

基因ID-1

8850

SwissProt

Q92831

背景

CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm . Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255). .