TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) Polyclonal Antibody

产品详情

产品名称

TAL1/2 (Acetyl Lys221/Acetyl Lys222/Acetyl Lys36/Acetyl Lys37) Polyclonal Antibody

产品货号

YM-A04174

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

45kD

宿主

Rabbit

同种型

IgG

修饰

Acetyl

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized acetyl-peptide derived from human TAL1/2 around the acetylation site of K221.

特异性

Acetyl-TAL1/2 (K221/K222/K36/K37) Polyclonal Antibody detects endogenous levels of TAL1/2 around the acetylation site of K221 protein.

基因名称

TAL1/TAL2

蛋白名称

T-cell acute lymphocytic leukemia protein 1 homolog/T-cell acute lymphocytic leukemia protein 2

别名

TAL1;BHLHA17;SCL;TCL5;T-cell acute lymphocytic leukemia protein 1;TAL-1;Class A basic helix-loop-helix protein 17;bHLHa17;Stem cell protein;T-cell leukemia/lymphoma protein 5;TAL2;BHLHA19;T-cell acute lymphocytic leukemia protein 2;TAL-2;Class A basic helix-loop-helix protein 19;bHLHa19

基因ID-1

6886

SwissProt

P17542

背景

alternative products:The splicing pattern is cell-lineage dependent,disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.,domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.,function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.,PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.,PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.,tissue specificity:Leukemic stem cell.,

细胞定位

Nucleus .