Tau (Acetyl Lys174) Polyclonal Antibody

产品详情

产品名称

Tau (Acetyl Lys174) Polyclonal Antibody

产品货号

YM-A04187

规格

50μL;100μL

种属反应

Human,Rat,Mouse

实验应用

WB,IF,ELISA

分子量

50-85kD

宿主

Rabbit

同种型

IgG

修饰

Acetyl

推荐稀释比

WB 1:500-2000;IF/ICC1:100-500;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthetic Acetyl peptide from human protein at AA range: 174

特异性

The antibody detects endogenous Tau when Acetyl occurs at Lys174

基因名称

MAPT MAPTL MTBT1 TAU

蛋白名称

Microtubule-associated protein tau (Neurofibrillary tangle protein) (Paired helical filament-tau) (PHF-tau)

别名

Microtubule-associated protein tau;Neurofibrillary tangle protein;Paired helical filament-tau;PHF-tau;

基因ID-1

4137

SwissProt

P10636

背景

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm, cytosol . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasm, cytoskeleton . Cell projection, axon . Cell projection, dendrite . Secreted . Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components (PubMed:10747907). Can be secreted; the secretion is dependent on protein unfolding and facilitated by the cargo receptor TMED10; it results in protein translocation from the cytoplasm into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) followed by vesicle entry and secretion (PubMed:32272059). .