PARP-1 (Acetyl-K521) Polyclonal Antibody

产品详情

产品名称

PARP-1 (Acetyl-K521) Polyclonal Antibody

产品货号

YM-A04194

规格

50μL;100μL

种属反应

Human:K521,Mouse:K520,Rat:K521

实验应用

WB,ELISA

分子量

宿主

Rabbit

同种型

IgG

修饰

Acetyl

推荐稀释比

WB 1:1000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized Acetyl peptide derived from human PARP-1. at AA range: K521

特异性

This antibody detects endogenous levels of PARP-1 at Human:K521;Mouse:K520;Rat:K521, It doesn't reacte with total protein.

基因名称

PARP1 ADPRT PPOL

蛋白名称

PARP-1

别名

Poly [ADP-ribose] polymerase 1;PARP-1;ADP-ribosyltransferase diphtheria toxin-like 1;ARTD1;NAD;+;ADP-ribosyltransferase 1;ADPRT 1;Poly[ADP-ribose] synthase 1;

基因ID-1

142

SwissProt

P09874

背景

This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus . Nucleus, nucleolus . Chromosome . Localizes to sites of DNA damage. .