p21 (Acetyl Lys161/K163) rabbit pAb

产品详情

产品名称

p21 (Acetyl Lys161/K163) rabbit pAb

产品货号

YM-A04267

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,ELISA

分子量

21kD

宿主

Rabbit

同种型

IgG

修饰

Acetyl

推荐稀释比

WB 1:1000-2000;ELISA 1:5000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human p21 (Acetyl Lys161/K163)

特异性

This antibody detects endogenous levels of Human,Mouse,Rat p21 (Acetyl Lys161/K163)

基因名称

CDKN1A CAP20 CDKN1 CIP1 MDA6 PIC1 SDI1 WAF1

蛋白名称

p21 (Acetyl Lys161/K163)

别名

Cyclin-dependent kinase inhibitor 1;CDK-interacting protein 1;Melanoma differentiation-associated protein 6;MDA-6;p21;

基因ID-1

1026

SwissProt

P38936

背景

function:May be the important intermediate by which p53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression.,induction:By p53, mezerein (antileukemic compound) and interferon beta.,PTM:Phosphorylation of Thr-145 by Akt or of Ser-146 by PKC impairs binding to PCNA.,similarity:Belongs to the CDI family.,tissue specificity:Expressed in all adult human tissues, with 5-fold lower levels observed in the brain.,

细胞定位

Cytoplasm . Nucleus .