Stat2 (Acetyl Lys384) rabbit pAb

产品详情

产品名称

Stat2 (Acetyl Lys384) rabbit pAb

产品货号

YM-A04277

规格

50μL;100μL

种属反应

Human,Rat

实验应用

WB,ELISA,IHC

分子量

73kD

宿主

Rabbit

同种型

IgG

修饰

Acetyl

推荐稀释比

WB 1:500-2000;IHC 1:50-300;ELISA 1:2000-20000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Polyclonal

克隆号

免疫原

Synthesized peptide derived from human Stat2 (Acetyl Lys384)

特异性

This antibody detects endogenous levels of Human,Rat Stat2 (Acetyl Lys384)

基因名称

STAT2

蛋白名称

Stat2 (Acetyl Lys384)

别名

Signal transducer and activator of transcription 2;p113;

基因ID-1

6773

SwissProt

P52630

背景

function:Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state.,PTM:Tyrosine phosphorylated in response to IFN-alpha.,similarity:Belongs to the transcription factor STAT family.,similarity:Contains 1 SH2 domain.,subcellular location:Translocated into the nucleus upon activation by IFN-alpha/beta.,subunit:Interacts with ISGF3G/IRF-9 in the cytoplasm. Heterodimer with STAT1 upon IFN-alpha/beta induced phosphorylation. Interacts with CRSP2 and CRSP6. Interacts with Simian virus 5 protein V and rabies virus phosphoprotein.,

细胞定位

Cytoplasm . Nucleus . Translocated into the nucleus upon activation by IFN-alpha/beta. .