CD45 Monoclonal Antibody

产品详情

产品名称

CD45 Monoclonal Antibody

产品货号

YM-A04394

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of CD45 expressed in E. Coli.

特异性

CD45 Monoclonal Antibody detects endogenous levels of CD45 protein.

基因名称

PTPRC

蛋白名称

Receptor-type tyrosine-protein phosphatase C

别名

PTPRC;CD45;Receptor-type tyrosine-protein phosphatase C;Leukocyte common antigen;L-CA;T200;CD antigen CD45

基因ID-1

5788

SwissProt

P08575

背景

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which enc

细胞定位

Cell membrane ; Single-pass type I membrane protein . Membrane raft . Colocalized with DPP4 in membrane rafts. .