Csk Monoclonal Antibody

产品详情

产品名称

Csk Monoclonal Antibody

产品货号

YM-A04421

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey

实验应用

WB,IF,Flow Cyt,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of human Csk expressed in E. Coli.

特异性

Csk Monoclonal Antibody detects endogenous levels of Csk protein.

基因名称

CSK

蛋白名称

Tyrosine-protein kinase CSK

别名

CSK;Tyrosine-protein kinase CSK;C-Src kinase;Protein-tyrosine kinase CYL

基因ID-1

1445

SwissProt

P41240

背景

catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.,function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases.,PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family.,similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.,similarity:Contains 1 protein kinase domain.,similarity:Contains 1 SH2 domain.,similarity:Contains 1 SH3 domain.,subcellular location:Mainly cytoplasmic, also present in lipid rafts.,subunit:Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1.,tissue specificity:Expressed in lung and macrophages.,

细胞定位

Cytoplasm . Cell membrane . Mainly cytoplasmic, also present in lipid rafts. .