IGF-IR Monoclonal Antibody

产品详情

产品名称

IGF-IR Monoclonal Antibody

产品货号

YM-A04545

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

pro:155kD,recetor beta:95kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of IGF-IR expressed in E. Coli.

特异性

IGF-IR Monoclonal Antibody detects endogenous levels of IGF-IR protein.

基因名称

IGF1R

蛋白名称

Insulin-like growth factor 1 receptor

别名

IGF1R;Insulin-like growth factor 1 receptor;Insulin-like growth factor I receptor;IGF-I receptor;CD antigen CD221

基因ID-1

3480

SwissProt

P08069

背景

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014],

细胞定位

Cell membrane ; Single-pass type I membrane protein .