LPL Monoclonal Antibody

产品详情

产品名称

LPL Monoclonal Antibody

产品货号

YM-A04596

规格

50μL;100μL

种属反应

Human

实验应用

WB,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of LPL expressed in E. Coli.

特异性

LPL Monoclonal Antibody detects endogenous levels of LPL protein.

基因名称

LPL

蛋白名称

Lipoprotein lipase

别名

LPL;LIPD;Lipoprotein lipase;LPL

基因ID-1

4023

SwissProt

P06858

背景

lipoprotein lipase(LPL) Homo sapiens LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008],

细胞定位

Cell membrane ; Peripheral membrane protein ; Extracellular side . Secreted . Secreted, extracellular space, extracellular matrix . Newly synthesized LPL binds to cell surface heparan proteoglycans and is then released by heparanase. Subsequently, it becomes attached to heparan proteoglycan on endothelial cells (PubMed:27811232). Locates to the plasma membrane of microvilli of hepatocytes with triglyceride-rich lipoproteins (TRL). Some of the bound LPL is then internalized and located inside non-coated endocytic vesicles (By similarity). .