LysRS Monoclonal Antibody

产品详情

产品名称

LysRS Monoclonal Antibody

产品货号

YM-A04600

规格

50μL;100μL

种属反应

Human

实验应用

WB,IHC,IF,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:200-1:1000;ELISA 1:10000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of LysRS(aa90-174) expressed in E. Coli.

特异性

LysRS Monoclonal Antibody detects endogenous levels of LysRS protein.

基因名称

KARS

蛋白名称

Lysyl-tRNA synthetase

别名

KARS;KIAA0070;Lysine--tRNA ligase;Lysyl-tRNA synthetase;LysRS

基因ID-1

3735

SwissProt

Q15046

背景

Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

细胞定位

[Isoform Cytoplasmic]: Cytoplasm, cytosol . Cytoplasm . Nucleus . Cell membrane ; Peripheral membrane protein . Secreted . Secretion is induced by TNF-alpha (PubMed:15851690). Cytosolic in quiescent mast cells. Translocates into the nucleus in response to mast cell activation by immunoglobulin E (PubMed:23159739). .; [Isoform Mitochondrial]: Mitochondrion .