Mi2-α Monoclonal Antibody

产品详情

产品名称

Mi2-α Monoclonal Antibody

产品货号

YM-A04614

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IHC,IF,Flow Cyt,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of human Mi2-α expressed in E. Coli.

特异性

Mi2-α Monoclonal Antibody detects endogenous levels of Mi2-α protein.

基因名称

CHD3

蛋白名称

Chromodomain-helicase-DNA-binding protein 3

别名

CHD3;Chromodomain-helicase-DNA-binding protein 3;CHD-3;ATP-dependent helicase CHD3;Mi-2 autoantigen 240 kDa protein;Mi2-alpha;Zinc finger helicase;hZFH

基因ID-1

1107

SwissProt

Q12873

背景

This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008],

细胞定位

Nucleus, PML body . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Associates with centrosomes in interphase and mitosis. .