RAG-2 Monoclonal Antibody

产品详情

产品名称

RAG-2 Monoclonal Antibody

产品货号

YM-A04688

规格

50μL;100μL

种属反应

Human

实验应用

WB,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of human RAG-2 (350-527aa) expressed in E. Coli.

特异性

RAG-2 Monoclonal Antibody detects endogenous levels of RAG-2 protein.

基因名称

RAG2

蛋白名称

V(D)J recombination-activating protein 2

别名

RAG2;V;D;J recombination-activating protein 2;RAG-2

基因ID-1

5897

SwissProt

P55895

背景

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodef

细胞定位

Nucleus .