TORC2 Monoclonal Antibody

产品详情

产品名称

TORC2 Monoclonal Antibody

产品货号

YM-A04742

规格

50μL;100μL

种属反应

Human,Monkey

实验应用

WB,IHC,IF,Flow Cyt,ELISA

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;IHC 1:200-1:1000;IF 1:200-1:1000;Flow Cyt 1:200-1:400;ELISA 1:10000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant fragment of human TORC2 expressed in E. Coli.

特异性

TORC2 Monoclonal Antibody detects endogenous levels of TORC2 protein.

基因名称

CRTC2

蛋白名称

CREB-regulated transcription coactivator 2

别名

CRTC2;TORC2;CREB-regulated transcription coactivator 2;Transducer of regulated cAMP response element-binding protein 2;TORC-2;Transducer of CREB protein 2

基因ID-1

200186

SwissProt

Q53ET0

背景

This gene encodes a member of the transducers of regulated cAMP response element-binding protein activity family of transcription coactivators. These proteins promote the transcription of genes targeted by the cAMP response element-binding protein, and therefore play an important role in many cellular processes. Under basal conditions the encoded protein is phosphorylated by AMP-activated protein kinase or the salt-inducible kinases and is sequestered in the cytoplasm. Upon activation by elevated cAMP or calcium, the encoded protein translocates to the nucleus and increases target gene expression. Single nucleotide polymorphisms in this gene may increase the risk of type 2 diabetes. A pseudogene of this gene is located on the long arm of chromosome 5. [provided by RefSeq, Dec 2010],

细胞定位

Cytoplasm . Nucleus . Translocated from the nucleus to the cytoplasm on interaction of the phosphorylated form with 14-3-3 protein (PubMed:15454081). In response to cAMP levels and glucagon, relocated to the nucleus (PubMed:15454081). .