Actinin-α2 Monoclonal Antibody

产品详情

产品名称

Actinin-α2 Monoclonal Antibody

产品货号

YM-A04764

规格

50μL;100μL

种属反应

Human,Rat,Bovine,Chicken,Dog,Pig,Zebrafish

实验应用

WB,IF

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human Actinin-α2 (C-terminus) protein fragments expressed in E.coli.

特异性

Actinin-α2 Monoclonal Antibody detects endogenous levels of Actinin-α2 protein.

基因名称

ACTN2/ACTN3

蛋白名称

Alpha-actinin-2

别名

ACTN2;Alpha-actinin-2;Alpha-actinin skeletal muscle isoform 2;F-actin cross-linking protein

基因ID-1

88

SwissProt

P35609

背景

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013],

细胞定位

Cytoplasm, myofibril, sarcomere, Z line . Colocalizes with MYOZ1 and FLNC at the Z-lines of skeletal muscle.