Arrestin-β-2 Monoclonal Antibody

产品详情

产品名称

Arrestin-β-2 Monoclonal Antibody

产品货号

YM-A04769

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Pig

实验应用

WB,IF

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human Arrestin-β-2 (C-terminus) protein fragments expressed in E.coli.

特异性

Arrestin-β-2 Monoclonal Antibody detects endogenous levels of Arrestin-β-2 protein.

基因名称

ARRB2

蛋白名称

Beta-arrestin-2

别名

ARRB2;ARB2;ARR2;Beta-arrestin-2;Arrestin beta-2

基因ID-1

409

SwissProt

P32121

背景

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 2, like arrestin beta 1, was shown to inhibit beta-adrenergic receptor function in vitro. It is expressed at high levels in the central nervous system and may play a role in the regulation of synaptic receptors. Besides the brain, a cDNA for arrestin beta 2 was isolated from thyroid gland, and thus it may also be involved in hormone-specific desensitization of TSH receptors. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012],

细胞定位

Cytoplasm. Nucleus. Cell membrane. Membrane, clathrin-coated pit . Cytoplasmic vesicle. Translocates to the plasma membrane and colocalizes with antagonist-stimulated GPCRs.