Crk II Monoclonal Antibody

产品详情

产品名称

Crk II Monoclonal Antibody

产品货号

YM-A04776

规格

50μL;100μL

种属反应

Human,Mouse,Dog,Rabbit

实验应用

WB

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human Crk II protein fragments expressed in E.coli.

特异性

Crk II Monoclonal Antibody detects endogenous levels of Crk II protein.

基因名称

CRK

蛋白名称

Adapter molecule crk

别名

CRK;Adapter molecule crk;Proto-oncogene c-Crk;p38

基因ID-1

1398

SwissProt

P46108

背景

This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .