CYP7A1 Monoclonal Antibody

产品详情

产品名称

CYP7A1 Monoclonal Antibody

产品货号

YM-A04778

规格

50μL;100μL

种属反应

Human,Golden hamster

实验应用

WB

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human CYP7A1 (C-terminus) protein fragments expressed in E.coli.

特异性

CYP7A1 Monoclonal Antibody detects endogenous levels of CYP7A1 protein.

基因名称

CYP7A1

蛋白名称

Cholesterol 7-alpha-monooxygenase

别名

CYP7A1;CYP7;Cholesterol 7-alpha-monooxygenase;CYPVII;Cholesterol 7-alpha-hydroxylase;Cytochrome P450 7A1

基因ID-1

1581

SwissProt

P22680

背景

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010],

细胞定位

Endoplasmic reticulum membrane ; Single-pass membrane protein . Microsome membrane ; Single-pass membrane protein .