HAUSP Monoclonal Antibody

产品详情

产品名称

HAUSP Monoclonal Antibody

产品货号

YM-A04786

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Dog,Pig

实验应用

WB,IF

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human HAUSP (C-terminus) protein fragments expressed in E.coli.

特异性

HAUSP Monoclonal Antibody detects endogenous levels of HAUSP protein.

基因名称

USP7

蛋白名称

Ubiquitin carboxyl-terminal hydrolase 7

别名

USP7;HAUSP;Ubiquitin carboxyl-terminal hydrolase 7;Deubiquitinating enzyme 7;Herpesvirus-associated ubiquitin-specific protease;Ubiquitin thioesterase 7;Ubiquitin-specific-processing protease 7

基因ID-1

7874

SwissProt

Q93009

背景

The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016],

细胞定位

Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.