PDH-E1α Monoclonal Antibody

产品详情

产品名称

PDH-E1α Monoclonal Antibody

产品货号

YM-A04810

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Bovine,Dog,Pig

实验应用

WB,IF

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;IF 1:100-1:500;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human PDH-E1α (C-terminus) protein fragments expressed in E.coli.

特异性

PDH-E1α Monoclonal Antibody detects endogenous levels of PDH-E1α protein.

基因名称

PDHA1 ODPA

蛋白名称

Pyruvate dehydrogenase E1 component subunit alpha somatic form mitochondrial

别名

PDHA1;PHE1A;Pyruvate dehydrogenase E1 component subunit alpha;somatic form, mitochondrial;PDHE1-A type I

基因ID-1

5160

SwissProt

P08559

背景

The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 alpha 1 subunit containing the E1 active site, and plays a key role in the function of the PDH complex. Mutations in this gene are associated with pyruvate dehydrogenase E1-alpha deficiency and X-linked Leigh syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010],

细胞定位

Mitochondrion matrix.