SOX-2 Monoclonal Antibody

产品详情

产品名称

SOX-2 Monoclonal Antibody

产品货号

YM-A04832

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Bovine,Pig,sheep

实验应用

WB

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-1:2000;Not yet tested in other applications.

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

Affinity purification

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human SOX-2 protein fragments expressed in E.coli.

特异性

SOX-2 Monoclonal Antibody detects endogenous levels of SOX-2 protein.

基因名称

SOX2

蛋白名称

Transcription factor SOX-2

别名

SOX2;Transcription factor SOX-2

基因ID-1

6657

SwissProt

P48431

背景

SRY-box 2(SOX2) Homo sapiens This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008],

细胞定位

Nucleus speckle . Cytoplasm . Nucleus . Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (By similarity). Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity). Colocalizes with SOX6 in speckles. Colocalizes with CAML in the nucleus (By similarity). Nuclear import is facilitated by XPO4, a protein that usually acts as a nuclear export signal receptor (By similarity). .