HAUSP/USP7 mouse mAb

产品详情

产品名称

HAUSP/USP7 mouse mAb

产品货号

YM-A04883

规格

50μL;100μL

种属反应

Human

实验应用

WB

分子量

135kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human HAUSP / USP7 protein fragments expressed in E.coli.

特异性

This antibody detects endogenous levels of HAUSP / USP7 and does not cross-react with related proteins.

基因名称

usp7

蛋白名称

别名

Deubiquitinating enzyme 7;HAUSP;herpes virus associated;Herpes virus associated ubiquitin specific protease;Herpesvirus-associated ubiquitin-specific protease;TEF 1;tef-1;TEF1;Ubiquitin carboxyl terminal hydrolase 7;Ubiquitin carboxyl-terminal hydrolase 7;Ubiquitin specific peptidase 7;herpes virus associated;Ubiquitin specific peptidase 7;Ubiquitin specific peptidase 7 herpes virus associated;Ubiquitin specific processing protease 7;Ubiquitin specific protease 7;herpes virus associated;Ubiquitin Specific Protease 7;Ubiquitin specific protease 7 herpes virus associated;Ubiquitin thioesterase 7;ubiquitin thiolesterase 7;Ubiquitin-specific-processing protease 7;UBP 7;UBP-7;UBP7;UBP7_HUMAN;USP 7;usp-7;USP7;VMW110-ASSOCIATED PROTEIN,135-KD.

基因ID-1

7874

SwissProt

Q93009

背景

The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. [provided by RefSeq, Mar 2016],

细胞定位

Nucleus . Cytoplasm . Nucleus, PML body . Chromosome . Present in a minority of ND10 nuclear bodies. Association with ICP0/VMW110 at early times of infection leads to an increased proportion of USP7-containing ND10. Colocalizes with ATXN1 in the nucleus. Colocalized with DAXX in speckled structures. Colocalized with PML and PTEN in promyelocytic leukemia protein (PML) nuclear bodies.