MEK1 mouse mAb

产品详情

产品名称

MEK1 mouse mAb

产品货号

YM-A04891

规格

50μL;100μL

种属反应

Human

实验应用

WB

分子量

45kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Recombinant human MEK1 protein.

特异性

This antibody detects endogenous levels of MEK1/2 and does not cross-react with related proteins.

基因名称

MEK1/2

蛋白名称

别名

AA589381;Dual specificity mitogen-activated protein kinase kinase 1;Dual specificity mitogen-activated protein kinase kinase 2;ERK activator kinase 1;ERK activator kinase 2;FLJ26075;MAP kinase kinase 1;MAP kinase kinase 2;MAP2K1;MAP2K2;MAPK/ERK kinase 1;MAPK/ERK kinase 2;MAPKK 1;MAPKK1;MAPKK2;MEK 1;MEKK1;Mitogen activated protein kinase kinase 1;Mitogen activated protein kinase kinase 2;Mitogen-activated protein kinase kinase 2, p45;MK2;MKK 1;MKK 2;MKK1;MKK2;MP2K1_HUMAN;PRKMK 1;PRKMK 2;Prkmk1;Prkmk2;protein kinase, mitogen-activated, kinase 1;MAP kinase kinase 1;Protein kinase, mitogen-activated, kinase 1;Protein kinase, mitogen-activated, kinase 2.

基因ID-1

56045605

SwissProt

P36507;Q02750

背景

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008],

细胞定位

extracellular region,nucleus,cytoplasm,mitochondrion,early endosome,late endosome,peroxisomal membrane,endoplasmic reticulum,Golgi apparatus,cytosol,microtubule,cell-cell junction,focal adhesio