GSK3 β mouse mAb

产品详情

产品名称

GSK3 β mouse mAb

产品货号

YM-A04897

规格

50μL;100μL

种属反应

Human,Mouse

实验应用

WB,IF,IP

分子量

46kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000;ICC 1:200;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant GSK-3β protein fragments expressed in E.coli.

特异性

This antibody detects endogenous levels of GSK-3β and does not cross-react with related proteins.

基因名称

gsk-3 beta

蛋白名称

别名

Glycogen Synthase Kinase 3 Beta;Glycogen synthase kinase-3 beta;GSK 3 beta;GSK-3 beta;GSK3B;GSK3B_HUMAN;GSK3beta isoform;Serine/threonine-protein kinase GSK3B.

基因ID-1

2932

SwissProt

P49841

背景

The protein encoded by this gene is a serine-threonine kinase, belonging to the glycogen synthase kinase subfamily. It is involved in energy metabolism, neuronal cell development, and body pattern formation. Polymorphisms in this gene have been implicated in modifying risk of Parkinson disease, and studies in mice show that overexpression of this gene may be relevant to the pathogenesis of Alzheimer disease. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009],

细胞定位

Cytoplasm . Nucleus . Cell membrane . The phosphorylated form shows localization to cytoplasm and cell membrane (PubMed:20937854). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854). .