CDC2/CDK1 mouse mAb

产品详情

产品名称

CDC2/CDK1 mouse mAb

产品货号

YM-A04914

规格

50μL;100μL

种属反应

Human

实验应用

WB,ICC

分子量

34kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:100;ICC 1:50

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human CDC2/CDK1 protein fragments expressed in E.coli.

特异性

This antibody detects endogenous levels of CDC2/CDK1 and does not cross-react with related proteins.

基因名称

cdk1

蛋白名称

别名

Cdc 2;Cdc2;CDC28A;CDK 1;CDK1;CDK1_HUMAN;CDKN1;CELL CYCLE CONTROLLER CDC2;Cell division control protein 2;Cell division control protein 2 homolog;Cell division cycle 2 G1 to S and G2 to M;Cell division protein kinase 1;Cell Divsion Cycle 2 Protein;Cyclin Dependent Kinase 1;Cyclin-dependent kinase 1;DKFZp686L20222;MGC111195;p34 Cdk1;p34 protein kinase;P34CDC2.

基因ID-1

983

SwissProt

P06493

背景

cyclin dependent kinase 1(CDK1) Homo sapiens The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G1/S and G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009],

细胞定位

Nucleus. Cytoplasm. Mitochondrion . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Cytoplasm, cytoskeleton, spindle. Cytoplasmic during the interphase. Colocalizes with SIRT2 on centrosome during prophase and on splindle fibers during metaphase of the mitotic cell cycle. Reversibly translocated from cytoplasm to nucleus when phosphorylated before G2-M transition when associated with cyclin-B1. Accumulates in mitochondria in G2-arrested cells upon DNA-damage.