SWAP70 mouse mAb

产品详情

产品名称

SWAP70 mouse mAb

产品货号

YM-A04953

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Monkey

实验应用

WB,IP

分子量

70kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

免疫原

Purified recombinant human SWAP70 protein fragments expressed in E.coli.

特异性

This antibody detects endogenous levels of SWAP70 and does not cross-react with related proteins.

基因名称

swap70

蛋白名称

别名

KIAA0640;70kDa;AV235546;FLJ39540;HSPC321;SWA 70 protein;SWAP 70;SWAP switching B-cell complex 70kDa subunit;SWAP-70;SWAP70;Switch associated protein 70;Switch-associated protein 70;SWP70_HUMAN.

基因ID-1

23075

SwissProt

Q9UH65

背景

domain:The PH domain is essential for phosphatidylinositol 3,4,5-trisphosphate binding.,function:Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion.,PTM:Tyrosine-phosphorylated.,similarity:Contains 1 PH domain.,subcellular location:In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus. In activated, class-switching B-cells it is associated with membrane IgG but not IgM. Localized to loose actin filament arrays located behind actively extending lamellipodia.,subunit:The SWAP complex consists of NPM1, NCL, PARP1 and SWAP70.,tissue specificity:Expressed only in mature B-cells including those associated with mucosa-associated tissue and bronchus-associated tissue (PubMed:10681448). Widely expressed. Abundant in spleen, and fairly abundant in kidney, lung and liver. Also found in monocytes and macrophages (PubMed:12925760).,

细胞定位

Cytoplasm . Cell membrane. Nucleus . Cell projection, lamellipodium . Cytoplasm, cytoskeleton . In resting B-cells it is localized mainly in the cytoplasm and upon cell activation it is recruited to the plasma membrane and then translocates to the nucleus (PubMed:10681448). In activated, class-switching B-cells it is associated with membrane IgG but not IgM (PubMed:10681448). Localized to loose actin filament arrays located behind actively extending lamellipodia (PubMed:12925760). .