Aquaporin 4 Monoclonal Antibody(4H1)

产品详情

产品名称

Aquaporin 4 Monoclonal Antibody(4H1)

产品货号

YM-A05302

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF

分子量

48kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000;IF 1:100-200;IHC 1:50-300

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

4H1

免疫原

Synthetic Peptide of Aquaporin 4

特异性

The antibody detects endogenous Aquaporin 4 proteins.

基因名称

AQP4

蛋白名称

Aquaporin-4

别名

AQP4;Aquaporin-4;AQP-4;Mercurial-insensitive water channel;MIWC;WCH4

基因ID-1

361

SwissProt

P55087

背景

This gene encodes a member of the aquaporin family of intrinsic membrane proteins that function as water-selective channels in the plasma membranes of many cells. This protein is the predominant aquaporin found in brain and has an important role in brain water homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2015],

细胞定位

Cell membrane ; Multi-pass membrane protein . Basolateral cell membrane ; Multi-pass membrane protein . Endosome membrane . Cell membrane, sarcolemma ; Multi-pass membrane protein . Cell projection . Activation of the vasopressin receptor AVPR1A triggers AQP4 phosphorylation at Ser-180 and promotes its internalization from the cell membrane. Detected on brain astrocyte processes and astrocyte endfeet close to capillaries. .