CD4 Monoclonal Antibody(11A1)

产品详情

产品名称

CD4 Monoclonal Antibody(11A1)

产品货号

YM-A05309

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC

分子量

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

IHC 1:200

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

11A1

免疫原

Synthetic Peptide of CD4

特异性

The antibody detects endogenous CD4 proteins.

基因名称

CD4

蛋白名称

T-cell surface glycoprotein CD4

别名

CD4;T-cell surface glycoprotein CD4;T-cell surface antigen T4/Leu-3;CD4

基因ID-1

920

SwissProt

P01730

背景

This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010],

细胞定位

Cell membrane ; Single-pass type I membrane protein . Localizes to lipid rafts (PubMed:12517957, PubMed:9168119). Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.