IDE Monoclonal Antibody(3H4)

产品详情

产品名称

IDE Monoclonal Antibody(3H4)

产品货号

YM-A05318

规格

50μL;100μL

种属反应

Human,Hamster

实验应用

WB,IHC,IF,

分子量

118kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000;IF 1:200;IHC 1:50-300

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

3H4

免疫原

Synthetic Peptide of IDE

特异性

The antibody detects endogenous IDE proteins.

基因名称

IDE

蛋白名称

Insulin-degrading enzyme

别名

IDE;Insulin-degrading enzyme;Abeta-degrading protease;Insulin protease;Insulinase;Insulysin

基因ID-1

3416

SwissProt

P14735

背景

This gene encodes a zinc metallopeptidase that degrades intracellular insulin, and thereby terminates insulins activity, as well as participating in intercellular peptide signalling by degrading diverse peptides such as glucagon, amylin, bradykinin, and kallidin. The preferential affinity of this enzyme for insulin results in insulin-mediated inhibition of the degradation of other peptides such as beta-amyloid. Deficiencies in this protein's function are associated with Alzheimer's disease and type 2 diabetes mellitus but mutations in this gene have not been shown to be causitive for these diseases. This protein localizes primarily to the cytoplasm but in some cell types localizes to the extracellular space, cell membrane, peroxisome, and mitochondrion. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been describe

细胞定位

Cytoplasm, cytosol . Cell membrane . Secreted . Present at the cell surface of neuron cells. The membrane-associated isoform is approximately 5 kDa larger than the known cytosolic isoform.