eIF4A1 Monoclonal Antibody(M8)

产品详情

产品名称

eIF4A1 Monoclonal Antibody(M8)

产品货号

YM-A05354

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF

分子量

48kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-3000;IF 1:100-200;IHC 1:50-300

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

M8

免疫原

Synthetic Peptide of eIF4A1

特异性

The antibody detects endogenous eIF4A1 protein.

基因名称

EIF4A1

蛋白名称

Eukaryotic initiation factor 4A-I

别名

Eukaryotic initiation factor 4A-I;eIF-4A-I;eIF4A-I;ATP-dependent RNA helicase eIF4A-1;

基因ID-1

1973

SwissProt

P60842

背景

function:ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.,similarity:Belongs to the DEAD box helicase family.,similarity:Belongs to the DEAD box helicase family. eIF4A subfamily.,similarity:Contains 1 helicase ATP-binding domain.,similarity:Contains 1 helicase C-terminal domain.,subunit:eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E and EIF4G1/EIF4G3. Interacts with PAIP1, EIF4E and RENT2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. May interact with NOM1.,

细胞定位

nucleus,cytoplasm,cytosol,membrane,eukaryotic translation initiation factor 4F complex,extracellular matrix,extracellular exosome,