IRF3 Mouse mAb(5H10)

产品详情

产品名称

IRF3 Mouse mAb(5H10)

产品货号

YM-A05391

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,WB

分子量

45-55kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

IHC1:50-200;WB 1:1000-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

5H10

免疫原

Synthesized peptide derived from human IRF3

特异性

This antibody detects endogenous levels of IRF3 at Human, Mouse,Rat

基因名称

IRF3

蛋白名称

IRF3

别名

Interferon regulatory factor 3;IRF-3;

基因ID-1

3661

SwissProt

Q14653

背景

This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011],

细胞定位

Cytoplasm . Nucleus . Mitochondrion . Shuttles between cytoplasmic and nuclear compartments, with export being the prevailing effect (PubMed:10805757). When activated, IRF3 interaction with CREBBP prevents its export to the cytoplasm (PubMed:10805757). Recruited to mitochondria via TOMM70:HSP90AA1 upon Sendai virus infection (PubMed:25609812). .