Rho A Mouse mAb(4E12)

产品详情

产品名称

Rho A Mouse mAb(4E12)

产品货号

YM-A05410

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

IHC,WB

分子量

22kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

IHC1:50-200;WB 1:1000-2000

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

4E12

免疫原

Synthesized peptide derived from human Rho A

特异性

This antibody detects endogenous levels of Rho A at Human, Mouse,Rat

基因名称

RHOA ARH12 ARHA RHO12

蛋白名称

Rho A

别名

Transforming protein RhoA;Rho cDNA clone 12;h12;

基因ID-1

387

SwissProt

P61586

背景

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. Overexpression of this gene is associated with tumor cell proliferation and metastasis. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015],

细胞定位

Cell membrane; Lipid-anchor; Cytoplasmic side. Cytoplasm, cytoskeleton. Cleavage furrow. Cytoplasm, cell cortex . Midbody. Cell projection, lamellipodium . Cell projection, dendrite . Nucleus . Localized to cell-cell contacts in calcium-treated keratinocytes (By similarity). Translocates to the equatorial region before furrow formation in a ECT2-dependent manner. Localizes to the equatorial cell cortex (at the site of the presumptive furrow) in early anaphase in an activated form and in a myosin- and actin-independent manner. .