Active Caspase-3 Monoclonal Antibody(5E1)

产品详情

产品名称

Active Caspase-3 Monoclonal Antibody(5E1)

产品货号

YM-A05449

规格

50μL;100μL

种属反应

Human,Mouse,Rat,Chicken

实验应用

IF,WB,IP,IHC

分子量

17kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

IF 1:50-200;WB 1:500-1000;IHC 1:100-200

组成

PBS, pH 7.4, containing 0.5%BSA, 0.02% sodium azide as Preservative and 50% Glycerol.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

5E1

免疫原

Recombinant Protein of Active Caspase-3

特异性

The antibody detects endogenous cleaved Caspase-3 protein p17 isoform.

基因名称

CASP3

蛋白名称

Caspase3

别名

CASP3;CPP32;Caspase-3;CASP-3;Apopain;Cysteine protease CPP32;CPP-32;Protein Yama;SREBP cleavage activity 1;SCA-1

基因ID-1

836

SwissProt

P42574

背景

This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 6, 7 and 9, and the protein itself is processed by caspases 8, 9 and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. Alternative splicing of this gene results in two transcript variants that encode the same protein. [provided by RefSeq, Jul 2008],

细胞定位

Cytoplasm.