Beclin-1 mouse Monoclonal Antibody(5C2)

产品详情

产品名称

Beclin-1 mouse Monoclonal Antibody(5C2)

产品货号

YM-A05509

规格

50μL;100μL

种属反应

Human,Rat,Mouse,Bovine

实验应用

WB,IHC,IF

分子量

60kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-2000;IHC 1:100-200;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

5C2

免疫原

Synthetic Peptide of Beclin-1 at AA range of 110-190

特异性

Beclin-1 protein detects endogenous levels of BECN1

基因名称

BECN1

蛋白名称

BECN1

别名

BECN1

基因ID-1

8678

SwissProt

Q14457

背景

beclin 1(BECN1) Homo sapiens This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],

细胞定位

Cytoplasm . Golgi apparatus, trans-Golgi network membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Endoplasmic reticulum membrane ; Peripheral membrane protein . Mitochondrion membrane ; Peripheral membrane protein . Endosome . Cytoplasmic vesicle, autophagosome . Interaction with ATG14 promotes translocation to autophagosomes. Expressed in dendrites and cell bodies of cerebellar Purkinje cells (By similarity). .; [Beclin-1-C 35 kDa]: Mitochondrion . Nucleus . Cytoplasm .; [Beclin-1-C 37 kDa]: Mitochondrion .