MMP2 mouse Monoclonal Antibody(1H1)

产品详情

产品名称

MMP2 mouse Monoclonal Antibody(1H1)

产品货号

YM-A05513

规格

50μL;100μL

种属反应

Human,Rat,Mouse

实验应用

WB,IHC,IF

分子量

64，72kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

IHC 1:100-200;WB 1:500-2000;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

1H1

免疫原

Synthetic Peptide of MMP2 at AA range of INTERNAL

特异性

MMP2 protein detects endogenous levels of MMP2

基因名称

MMP2

蛋白名称

MMP2

别名

MMP2

基因ID-1

4313

SwissProt

P08253

背景

matrix metallopeptidase 2(MMP2) Homo sapiens This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction. The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Win

细胞定位

[Isoform 1]: Secreted, extracellular space, extracellular matrix . Membrane. Nucleus. Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.; [Isoform 2]: Cytoplasm. Mitochondrion.