CHOP mouse Monoclonal Antibody(2B1)

产品详情

产品名称

CHOP mouse Monoclonal Antibody(2B1)

产品货号

YM-A05514

规格

50μL;100μL

种属反应

Human,Rat,Mouse

实验应用

WB,IF,IHC

分子量

27kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:1000-2000;IHC 1:100-200;IF 1:200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

2B1

免疫原

Synthetic Peptide of CHOP at AA range of 10-90

特异性

CHOP protein detects endogenous levels of DDIT3

基因名称

DDIT3

蛋白名称

DDIT3

别名

DDIT3

基因ID-1

1649

SwissProt

P35638

背景

This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010],

细胞定位

Cytoplasm . Nucleus . Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation. .