HP-1γ mouse Monoclonal Antibody(3B9)

产品详情

产品名称

HP-1γ mouse Monoclonal Antibody(3B9)

产品货号

YM-A05519

规格

50μL;100μL

种属反应

Human,Mouse,Rat

实验应用

WB,IHC,IF

分子量

24kD

宿主

Mouse

同种型

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IHC 1:50-300;IF 1:50-200

组成

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

纯化工艺

The antibody was affinity-purified from mouse antiserum by affinity-chromatography using epitope-specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

3B9

免疫原

Recombinant Protein of HP-1γ

特异性

The antibody detects endogenous HP-1γ protein

基因名称

CBX3

蛋白名称

Chromobox protein homolog 3 (HECH) (Heterochromatin protein 1 homolog gamma) (HP1 gamma) (Modifier 2 protein)

别名

Chromobox protein homolog 3;HECH;Heterochromatin protein 1 homolog gamma;HP1 gamma;Modifier 2 protein;

基因ID-1

11335

SwissProt

Q13185

背景

At the nuclear envelope, the nuclear lamina and heterochromatin are adjacent to the inner nuclear membrane. The protein encoded by this gene binds DNA and is a component of heterochromatin. This protein also can bind lamin B receptor, an integral membrane protein found in the inner nuclear membrane. The dual binding functions of the encoded protein may explain the association of heterochromatin with the inner nuclear membrane. This protein binds histone H3 tails methylated at Lys-9 sites. This protein is also recruited to sites of ultraviolet-induced DNA damage and double-strand breaks. Two transcript variants encoding the same protein but differing in the 5' UTR, have been found for this gene.[provided by RefSeq, Mar 2011],

细胞定位

Nucleus . Associates with euchromatin and is largely excluded from constitutive heterochromatin. May be associated with microtubules and mitotic poles during mitosis (Potential). .