VEGF-A (PT0865) Mouse mAb

产品详情

产品名称

VEGF-A (PT0865) Mouse mAb

产品货号

YM-A05556

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

WB,IF,ELISA

分子量

37kD

宿主

Mouse

同种型

IgG1,Kappa

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein G

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

PT0865

免疫原

The antiserum was produced against synthesized peptide derived from human VEGF-A. AA range: 100-200

特异性

This antibody detects endogenous levels of VEGF-A protein.

基因名称

VEGFA

蛋白名称

Vascular endothelial growth factor A

别名

VEGFA;VEGF;Vascular endothelial growth factor A;VEGF-A;Vascular permeability factor;VPF

基因ID-1

7422

SwissProt

P15692

背景

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation fro

细胞定位

Cytoplasmic