TFE3 (PT2169) mouse mAb

产品详情

产品名称

TFE3 (PT2169) mouse mAb

产品货号

YM-A05588

规格

50μL;100μL

种属反应

Human,Mouse,Bovin,

实验应用

WB,IF,IP,ELISA

分子量

62kD

宿主

Mouse

同种型

IgG1,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein G

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

PT2169

免疫原

Synthesized peptide derived from human TFE3 AA range: 100-200

特异性

This antibody detects endogenous levels of TFE3 protein.

基因名称

TFE3 BHLHE33

蛋白名称

Transcription factor E3 (Class E basic helix-loop-helix protein 33) (bHLHe33)

别名

基因ID-1

7030

SwissProt

P19532

背景

transcription factor binding to IGHM enhancer 3(TFE3) Homo sapiens This gene encodes a basic helix-loop-helix domain-containing transcription factor that binds MUE3-type E-box sequences in the promoter of genes. The encoded protein promotes the expression of genes downstream of transforming growth factor beta (TGF-beta) signaling. This gene may be involved in chromosomal translocations in renal cell carcinomas and other cancers, resulting in the production of fusion proteins. Translocation partners include PRCC (papillary renal cell carcinoma), NONO (non-POU domain containing, octamer-binding), and ASPSCR1 (alveolar soft part sarcoma chromosome region, candidate 1), among other genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],

细胞定位

Cytoplasmic, Nuclear