CD40 (PTR1379) recombinant mouse mAb

产品详情

产品名称

CD40 (PTR1379) recombinant mouse mAb

产品货号

YM-A05602

规格

50μL;100μL

种属反应

Human

实验应用

Flow Cyt,ELISA

分子量

30kD

宿主

Mouse

同种型

IgG1,Kappa

修饰

Unmodified

推荐稀释比

ELISA 1:5000-100000;Flow Cyt 1-2μg/Test

组成

Phosphate-buffered solution

纯化工艺

Recombinant Expression and Affinity purified

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

Please check the information on the tube

克降性

Monoclonal

克隆号

PTR1379

免疫原

Purified recombinant human CD40.

特异性

This recombinant monoclonal antibody can detects endogenous levels of CD40 protein.

基因名称

CD40

蛋白名称

Tumor necrosis factor receptor superfamily member 5

别名

CD40;TNFRSF5;Tumor necrosis factor receptor superfamily member 5;B-cell surface antigen CD40;Bp50;CD40L receptor;CDw40;CD antigen CD40

基因ID-1

958

SwissProt

P25942

背景

This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIG

细胞定位

[Isoform I]: Cell membrane; Single-pass type I membrane protein.; [Isoform II]: Secreted.