MGMT (PTR2300) mouse mAb

产品详情

产品名称

MGMT (PTR2300) mouse mAb

产品货号

YM-A05634

规格

50μL;100μL

种属反应

Human,

实验应用

WB,IF,ELISA

分子量

22kD

宿主

Mouse

同种型

IgG2b,Kappa

修饰

Unmodified

推荐稀释比

WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein G

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

1 mg/ml

克降性

Monoclonal

克隆号

PTR2300

免疫原

Synthesized peptide derived from human MGMT AA range: 1-100

特异性

This antibody detects endogenous levels of MGMT protein.

基因名称

MGMT

蛋白名称

Methylated-DNA--protein-cysteine methyltransferase (6-O-methylguanine-DNA methyltransferase) (MGMT) (O-6-methylguanine-DNA-alkyltransferase)

别名

基因ID-1

4255

SwissProt

P16455

背景

O-6-methylguanine-DNA methyltransferase(MGMT) Homo sapiens Alkylating agents are potent carcinogens that can result in cell death, mutation and cancer. The protein encoded by this gene is a DNA repair protein that is involved in cellular defense against mutagenesis and toxicity from alkylating agents. The protein catalyzes transfer of methyl groups from O(6)-alkylguanine and other methylated moieties of the DNA to its own molecule, which repairs the toxic lesions. Methylation of the genes promoter has been associated with several cancer types, including colorectal cancer, lung cancer, lymphoma and glioblastoma. [provided by RefSeq, Sep 2015],

细胞定位

Nuclear