Oct-4 (PTR1369) mouse mAb

产品详情

产品名称

Oct-4 (PTR1369) mouse mAb

产品货号

YM-A05690

规格

50μL;100μL

种属反应

Human,

实验应用

WB,ELISA

分子量

40kD

宿主

Mouse

同种型

IgG2b,Kappa

修饰

Unmodified

推荐稀释比

WB 1:500-1:2000;ELISA 1:1000-5000.

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

The antibody was affinity-purified from ascites by affinity-chromatography using specific immunogen.

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

PTR1369

免疫原

Synthesized peptide derived from human Oct-4 AA range:50-150

特异性

This antibody detects endogenous levels of 4-Oct protein.

基因名称

POU5F1

蛋白名称

POU domain class 5 transcription factor 1

别名

POU5F1;OCT3;OCT4;OTF3;POU domain;class 5, transcription factor 1;Octamer-binding protein 3;Oct-3;Octamer-binding protein 4;Oct-4;Octamer-binding transcription factor 3;OTF-3

基因ID-1

5460

SwissProt

Q01860

背景

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013],

细胞定位

Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern. Colocalizes with MAPK8 and MAPK9 in the nucleus.