p120 catenin (ABT082) mouse mAb

产品详情

产品名称

p120 catenin (ABT082) mouse mAb

产品货号

YM-A05802

规格

50μL;100μL

种属反应

Human,Mouse,Rat,

实验应用

IHC,WB,IF,ELISA

分子量

108kD

宿主

Mouse

同种型

IgG2b,Kappa

修饰

Unmodified

推荐稀释比

IHC 1:200-1000;WB 1:500-2000;IF 1:100-500;ELISA 1:1000-5000

组成

PBS, 50% glycerol, 0.05% Proclin 300, 0.05%BSA

纯化工艺

Protein G

储存

-15°C to -25°C/1 year(Do not lower than -25°C)

浓度

克降性

Monoclonal

克隆号

ABT082

免疫原

Synthesized peptide derived from human p120 catenin AA range: 600-700

特异性

The antibody can specifically recognize human p120 catenin protein. In western blotting of Hela, A431 and HEK293 cell lysates, the antibody can label a band with molecular weight around 100~110 kDa.

基因名称

CTNND1 KIAA0384

蛋白名称

p120 catenin

别名

Cadherin associated Src substRate;Cadherin-associated Src substRate;CAS;Catenin;cadherin associated protein;delta 1;Catenin delta 1;Catenin delta;Catenin delta-1;CTND1_HUMAN;CTNND 1;CTNND;CTNND1;delta 1 Catenin;KIAA0384;p120;P120 CAS;p120 catenin;P120 CTN;p120;cas;p120;ctn;P120CAS;P120CTN

基因ID-1

1500

SwissProt

O60716

背景

α- Catenin、 β- Catenin、 γ- catenin and p120 catenin are members of the connexin family and mediate intercellular adhesion together with E-cadherin. P120 catenin binds to the near membrane region of E-cadherin to form a complex, which is stable and closely linked. In lobular breast cancer, E-cadherin deficiency resulted in the accumulation of p120 catenin in the cytoplasm, while in ductal breast cancer, p120 catenin in the membrane decreased and there was no accumulation of p120 catenin in the cytoplasm. Therefore, it can be used to distinguish lobular carcinoma from ductal carcinoma. Studies have shown that p120 catenin in the cytoplasm of gastric and colon cancer is related to poor adhesion of cancer cells.

细胞定位

Cytoplasmic, Membranous